Dissociable effects of local inhibitory and excitatory theta-burst stimulation on large-scale brain dynamics

L Cocchi; MV Sale; A Lord; A Zalesky; M Breakspear; JB Mattingley

Journal article

Dissociable effects of local inhibitory and excitatory theta-burst stimulation on large-scale brain dynamics

L Cocchi, MV Sale, A Lord, A Zalesky, M Breakspear, JB Mattingley

Journal of Neurophysiology | Published : 2015

DOI: 10.1152/jn.00850.2014

Abstract

Normal brain function depends on a dynamic balance between local specialization and large-scale integration. It remains unclear, however, how local changes in functionally specialized areas can influence integrated activity across larger brain networks. By combining transcranial magnetic stimulation with resting-state functional magnetic resonance imaging, we tested for changes in large-scale integration following the application of excitatory or inhibitory stimulation on the human motor cortex. After local inhibitory stimulation, regions encompassing the sensorimotor module concurrently increased their internal integration and decreased their communication with other modules of the brain. T..

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University of Melbourne Researchers

Andrew Zalesky Author

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Grants

Awarded by Australian Research Council (ARC) Australian Laureate Fellowship

Awarded by ARC Science of Learning Research Centre

Awarded by ARC Centre of Excellence for Integrative Brain Function (ARC Centre Grant)

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

This study was supported by a grant from the National and International Research Alliance Program (NIRAP), Queensland State Government, Australia. J. B. Mattingley was supported by an Australian Research Council (ARC) Australian Laureate Fellowship (FL110100103), the ARC Science of Learning Research Centre (SR120300015), and the ARC Centre of Excellence for Integrative Brain Function (ARC Centre Grant CE140100007). M. V. Sale and A. Zalesky were supported by the Australian National Health and Medical Research Council (APP1028210 to M. V. Sale and APP1047648 to A. Zalesky).